Medical Definition of Quin-2
1.
A fluorescent compound that binds calcium tightly and resembles the chelator EGTA in ability to bind calcium much more tightly than magnesium. Binding of calcium causes large changes in ultraviolet absorption and fluoresence.
The wavelengths of light that cause fluorescence when calcium is bound are longer than the wavelengths that cause fluorescence when it is not bound.
When excited at two different wavelengths, the ratio of the fluorescence intensities at the two wavelengths gives the ratio of the concentrations of bound to free calcium. Free quin-2 concentration can be measured precisely, so free calcium concentration can be calculated precisely.
Quin-2 may be injected into cells to measure moment-to-moment changes in intracellular calcium concentration.
Chemical name: (2-[(2-bis-[carboxymethyl]aono-5-methoxyphenyl)-methyl-6-methoxy-8-bis[carboxymethyl]aminoquinoline)
See: aequorin, fura-2.
(05 Mar 2000)
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