Definition of Secretase

1. Noun. A set of enzymes believed to snip pieces off a longer protein producing fragments of amyloid protein that bunch up and create amyloid protein plaques in brain tissue (the pathological hallmark of Alzheimer's).

Generic synonyms: Enzyme



Definition of Secretase

1. Noun. (biochemistry) An enzyme that "snips" pieces off a longer protein that is embedded in the cell membrane. ¹

¹ Source: wiktionary.com

Medical Definition of Secretase

1. Hypothetical proteinase which cleaves amyloid beta-precursor protein in betaa4 domain (residue 16) to generate the secreted form of app; comes in three putative forms (alpha, beta, gamma); beta and gamma forms form beta-protein from precursor, while alpha form cleaves precursor in middle so no beta-protein forms Registry number: EC 3.4.99.- Synonym: app secretase, amyloid precursor protein secretase, alpha-secretase, beta-secretase, gamma-secretase (26 Jun 1999)

Secretase Pictures

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Lexicographical Neighbors of Secretase

secretariate
secretariates
secretariats
secretaried
secretaries
secretary
secretary-general
secretary bird
secretary birds
secretarybird
secretarybirds
secretarying
secretarylike
secretaryship
secretaryships
secretase (current term)
secrete
secrete-metory
secreted
secreter
secreters
secretes
secretest
secretin
secretin test
secreting
secretins
secretion
secretion vector
secretionary

Literary usage of Secretase

Below you will find example usage of this term as found in modern and/or classical literature:

1. Novel Systems for the Study of Human Disease: From Basic Research to by OECD Staff, (Paris) Organisation for Economic Co-ope (1998)
"Normal processing by cx-secretase allows secretion of the ectodomain of APP ... To generate the B-amyloid peptide from APP the a-secretase cleavage must be ..."

2. Colección de documentos inéditos para la historia de España by Real Academia de la Historia (Spain) (1875)
"... quería que no fuese la fatiga suya y la gloria de otro, pues ambas cosas las habia beneficiado él; haciendo, pues, diligencias secretase! ..."

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