Medical Definition of Sodium channel

1. The protein responsible for electrical excitability of neurons. A transmembrane ion channel, containing an aqueous pore around 0.4nm diameter, with a negatively charged region internally (the selectivity filter) to block passage of anions. The channel is voltage gated: it opens in response to a small depolarisation of the cell (usually caused by an approaching action potential), by a multistep process. Around 1000 sodium ions pass in the next millisecond, before the channel spontaneously closes (an event with single step kinetics). The channel is then refractory to further depolarisations until returned to near the resting potential. There are around 100 channels per square micron in unmyelinated axons, in myelinated axons, they are concentrated at the nodes of Ranvier. The sodium channel is the target of many of the deadliest neurotoxins. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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Lexicographical Neighbors of Sodium Channel

sodium aurothiosulfate
sodium azide
sodium benzoate
sodium bicarb
sodium bichromate
sodium biphosphate
sodium bisulfite
sodium bisulphite
sodium borate
sodium borohydride
sodium bromide
sodium cacodylate
sodium carbonate
sodium carboxymethyl cellulose
sodium channel (current term)
sodium channels
sodium chlorate
sodium chloride
sodium citrate
sodium citrate acid
sodium compounds
sodium cromoglycate
sodium cyanide
sodium dehydrocholate
sodium diatrizoate
sodium dichromate
sodium dihydrogen phosphate
sodium dimethylarsenate
sodium dodecyl sulfate

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