Medical Definition of Tissue inhibitor of metalloproteinases

1. A family of secreted proteins (timp-1, timp-2, and timp-3) that play a crucial role in regulating the activity of the secreted metalloproteinases (collagenases, stromelysins, gelatinases). Of the three characterised, only timp-1 and timp-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumourigenic and metastatic phenotype in cancer cells. (pharmacol ther 1993;59:329-41) Pharmacological action: antineoplastic agent, protease inhibitors. (12 Dec 1998)



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Lexicographical Neighbors of Tissue Inhibitor Of Metalloproteinases

tissue displaceability
tissue displacement
tissue distribution
tissue donors
tissue embedding
tissue engineering
tissue expanders
tissue expansion
tissue extracts
tissue factor
tissue fixation
tissue fluid
tissue hormones
tissue inhibitor-of metalloproteinase-2
tissue inhibitor of-metalloproteinase-3
tissue inhibitor of metalloproteinases (current term)
tissue inhibitors of metalloproteinase
tissue layer
tissue lymph
tissue molding
tissue paper
tissue perfusion
tissue plasminogen activator
tissue polypeptide antigen
tissue preservation
tissue procollagenase
tissue registration
tissue respiration
tissue survival
tissue tension

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