Definition of What's up with

1. Phrase. (colloquial rhetorical question) Used to express disbelief or curiosity. ¹

2. Phrase. (colloquial rhetorical question salutation) Said to express that a person's behavior is out of the ordinary. ¹

¹ Source:

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Lexicographical Neighbors of What's Up With

what's it to you
what's new
what's on your mind
what's sauce for the goose is sauce for the gander
what's shaking
what's that
what's the big idea
what's the crack
what's the craic
what's the difference
what's the good of
what's the matter
what's the time
what's the time, Mr Wolf
what's up
what's up with
what's what
what's with
what's yer poison
what's your job
what's your name
what's your phone number
what's your poison
what's yours

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