Medical Definition of Zinostatin
1.
An antitumour isolate from the culture filtrate of the f-41 variant of streptomyces carzinostaticus. It is a protein of known amino acid sequence with a molecular weight of approximately 11,500 and possessing a regulatory function on the metabolism of DNA. In this process, that is first an inhibition of DNA biosynthesis followed by the degradation of DNA, zinostatin functions in a manner analogous to that of the much higher molecular weight antibiotic mitomycin c. Zinostatin is also a potent cytostatic agent active against gram-positive organisms.
Pharmacological action: antibiotics, antineoplastic, nucleic acid synthesis inhibitors.
Chemical name: Neocarzinostatin
(12 Dec 1998)
Lexicographical Neighbors of Zinostatin
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