Medical Definition of Hexose monophosphate shunt
1. The main metabolic pathway in activated neutrophils, rendering them relatively insensitive to inhibitors of oxidative phosphorylation. Congenital deficiency of the first enzyme in the shunt, glucose 6 phosphate dehydrogenase, produces a sensitivity to infection similar to that seen in chronic granulomatous disease. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)
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