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Medical Definition of Histocompatibility antigens class I
1. Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-a, HLA-b and HLA-c antigens. In mice, three genes named k, d, and l on chromosome 17 code for the h-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognised during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders. (12 Dec 1998)
Lexicographical Neighbors of Histocompatibility Antigens Class I
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