Medical Definition of Mixed connective tissue disease
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon.
The disease is differentially characterised by high serum titres of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen (nuclear ribonucleoprotein) and a speckled epidermal nuclear staining pattern on direct immunofluorescence.
A more modern term for this condition is the undifferentiated connective tissues disease.
(22 Sep 2002)
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