Lexic.us

Definition of Charcot-Marie-Tooth disease

1. Noun. A form of neuropathy that can begin between childhood and young adulthood; characterized by weakness and atrophy of the muscles of the hands and lower legs; progression is slow and individuals affected can have a normal life span; inheritance is X-linked recessive or X-linked dominant.

Medical Definition of Charcot-Marie-Tooth disease

1. A slowly progressive genetic disorder which is the most common of the inherited peripheral neuropathies, and encompasses a family of disorders characterised by distal muscle weakness and diminished nerve conduction velocity, due to the destruction of nerves with degeneration of the myelin sheath. Features include muscle atrophy in the feet and the legs, progressing to the hands and arms, often with foot drop and a slapping gait. The predominant variety, designated CMT1, is an autosomal dominant disorder caused, in most cases, by duplication of a very large (1.5 Mb) region on chromosome 17p11.2-12. A related condition, hereditary neuropathy with liability to pressure palsies (HNPP), is associated with a large deletion in the same general region. There is no specific treatment for this disorder. (16 Dec 1997)

Lexicographical Neighbors of Charcot-Marie-Tooth Disease

Literary usage of Charcot-Marie-Tooth disease

Below you will find example usage of this term as found in modern and/or classical literature:

1. Handbook of Severe Disability: A Text for Rehabilitation Counselors, Other edited by Walter C. Stolov, Michael R. Clowers (2000)
"A sampling of the major hereditary neuropathies includes: 1 Charcot-Marie-Tooth disease 2. Dejerine - Sottas disease 3. Hereditary sensory neuropathy Heavy ..."

2. Reviews in Environmental Health (1998): Toxicological Defense Mechanics edited by Gary E. R. Hook, George W. Lucier (2000)
"Connexin mutations in X-linked Charcot-Marie-Tooth disease. Science 262:2039-2042 (1993). 67. Britz-Cunningham SH, Shan MM, Zuppan CW, Fletcher WH. ..."

3. Monographic Medicine by Albion Walter Hewlett, Henry Leopold Elsner (1916)
"... Charcot-Marie-Tooth disease, and neural progressive muscular atrophy of Hoffmann, occurs usually in early life, before the twentieth ye;ir, ..."

4. Choosing a Wheelchair System edited by Seldon P. Todd, Jr. (1992)
"Case #3: Bill T. Bill T. is a 39-year-old male, diagnosed with Charcot-Marie-Tooth disease, a progressive hereditary neuropathy. The disease had progressed ..."

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