Medical Definition of DNA topoisomerase (ATP-hydrolysing)
1.
An ATP-requiring enzyme which, in the presence of magnesium ions, introduces negative supertwists into closed and possibly linear duplex DNA. The enzyme is implicated in DNA replication and transcription. It causes the storage of mechanical strain energy in the superhelical turns of DNA at the expense of ATP hydrolysis.
Chemical name: DNA topoisomerase (ATP-hydrolysing)
Registry number: EC 5.99.1.3
(12 Dec 1998)
Lexicographical Neighbors of DNA Topoisomerase (ATP-hydrolysing)
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