Medical Definition of Amyloid beta-protein precursor

1. A precursor to the amyloid-beta protein (beta/a4). Alterations in the expression of the amyloid beta-protein precursor (abpp) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both alzheimer disease and down syndrome. Abpp is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/a4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in alzheimer disease, down syndrome and, to a limited extent, in normal aging. (12 Dec 1998)

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Lexicographical Neighbors of Amyloid Beta-protein Precursor

amylocaine hydrochloride
amylogenic body
amyloid A-degrading serine protease
amyloid angiopathy
amyloid beta-protein
amyloid beta-protein precursor (current term)
amyloid bodies of the prostate
amyloid corpuscle
amyloid degeneration
amyloid nephrosis
amyloid neuropathies
amyloid p component
amyloid plaque
amyloid precursor protein
amyloid protein
amyloid protein aa
amyloid protein plaque
amyloid protein saa
amyloid tumour

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