Definition of Clavulanic acid
1. Noun. (medicine) An inhibitor of enzymatic hydrolysis that is added to penicillin antibiotics ¹
¹ Source: wiktionary.com
Medical Definition of Clavulanic acid
Clavulanic acid (c8h9o5n) and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.
Pharmacological action: antibiotics, lactam, enzyme inhibitors.
Chemical name: 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, (2R-(2alpha,3Z,5alpha))
(12 Dec 1998)
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