Medical Definition of Minimal-change nephrotic syndrome

1. A disorder of the kidneys which largely affects the glomerulus, the blood filtering structure. This disorder is one common cause of nephrotic syndrome, minimal glomerular changes, in children affecting 2 to 3 children per 100,000 population under age 16 in the USA. Minimal change disease is also seen rarely in adults. The cause is unknown but may be related to an autoimmune illness. It is marked by oedema, albuminuria, and an increase in cholesterol in the blood, but otherwise with fairly good renal function. Tubular epithelium is vacuolated by cholesterol droplets, but the glomeruli show only that the foot processes of the glomerular epithelial cells are fused, probably secondary to the proteinuria; the cause of the increased glomerular permeability to plasma protein is unknown. Risk factors include a history for a immune disorder, recent immunisation or a bee sting. Diagnosis is made by renal biopsy. Treatment include systemic corticosteroids which are usually quite effective in curing this disease. Other medications include chlorambucil and cyclophosphamide. In most cases, a moderate protein diet (1 gram protein per Kg body weight per day) will be recommended. Salt (sodium) restriction can be helpful to reduce swelling and vitamin D is usually supplemented. Synonym: lipoid nephrosis (27 Sep 1997)

Lexicographical Neighbors of Minimal-change Nephrotic Syndrome

minified
minifies
minify
minifying
minikin
minikins
minilab
minilabs
minilaparotomy
minim
minim
minima
minimal
minimal
minimal-change disease
minimal-change nephrotic syndrome (current term)
minimalism
minimalisms
minimalist
minimalists
minimally
minimally invasive coronary bypass surgery
minimals
minimal air
minimal alveolar concentration
minimal amplitude nystagmus
minimal anaesthetic concentration
minimal art
minimal brain damage
minimal brain dysfunction

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