Definition of Phase i clinical trial

1. Noun. A clinical trial on a few persons to determine the safety of a new drug or invasive medical device; for drugs, dosage or toxicity limits should be obtained.

Exact synonyms: Phase I
Generic synonyms: Clinical Test, Clinical Trial



Medical Definition of Phase i clinical trial

1. The earliest stage clinical trial for studying an experimental drug in humans. Phase I trials are generally comparatively small and are used to determine toxicity and maximum dose. They provide an initial evaluation of a drug's safety and pharmacokinetics-how the drug is absorbed, what tissues it reaches and how long it takes to leave the body. Such studies also usually test various doses of the drug (dose-ranging) to obtain an indication of the appropriate dose to use in later studies. The patients in these trials usually have advanced disease and have already received best available chemotherapy, therefore, seeing a repose is significant partially because this means there is a lack of cross-resistance between two anti-cancer drugs. (31 Dec 1997)

Phase I Clinical Trial Pictures

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Lexicographical Neighbors of Phase I Clinical Trial

phascolomes
phase
phase-amplitude contrast
phase-contrast microscope
phase-locked loop
phase-shift keying
phase I
phase II
phase III
phase III clinical trial
phase II block
phase II clinical trial
phase IV
phase IV clinical trials
phase I block
phase I clinical trial
phase angle
phase change
phase contrast
phase contrast microscope
phase contrast microscopy
phase diagram
phase encoding
phase function
phase functions
phase image
phase in
phase inverter
phase modulation
phase modulator

Literary usage of Phase i clinical trial

Below you will find example usage of this term as found in modern and/or classical literature:

1. New Developments and Applications in Experimental Design: Selected by Nancy Flournoy, William F. Rosenberger, Weng Kee Wong (1998)
"The objective of a phase I clinical trial is to determine a maximum tolerated dose (MTD), where response is generally dichotomous ("toxicity" or "no ..."

2. Adaptive Designs: Selected Proceedings of a 1992 Joint Ams-Ims-Siam Summer by Nancy Flournoy, William F. Rosenberger, American Mathematical Society, Institute of Mathematical Statistics (1995)
"... response function is equal to the prior for (3 that was elicited by Flournoy (1994) for estimating optimal treatment levels in a phase I clinical trial. ..."

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