Medical Definition of Thrombase

1. Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Lexicographical Neighbors of Thrombase

throbber
throbbers
throbbier
throbbiest
throbbing
throbbingly
throbbings
throbby
throbs
throe
throed
throeing
throes
thromb-
thromb-endarterectomy
thrombase (current term)
thrombasthenia
thrombectomies
thrombectomy
thrombelastography
thrombendarterectomy
thrombendarteriectomies
thrombendarteriectomy
thrombendoarterectomy
thrombi
thrombin
thrombin time
thrombinogen
thrombinogenesis
thrombins

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