Definition of Thrombin

1. Noun. An enzyme that acts on fibrinogen in blood causing it to clot.

Generic synonyms: Coagulase



Definition of Thrombin

1. n. The fibrin ferment which produces the formation of fibrin from fibrinogen.

Definition of Thrombin

1. Noun. (enzyme) An enzyme in blood that facilitates blood clotting by converting fibrinogen to fibrin (by means of ionized calcium). ¹

¹ Source: wiktionary.com

Definition of Thrombin

1. an enzyme [n -S] - See also: enzyme

Medical Definition of Thrombin

1. Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)

Thrombin Pictures

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Lexicographical Neighbors of Thrombin

throed
throeing
throes
thromb-
thromb-endarterectomy
thrombase
thrombasthenia
thrombectomies
thrombectomy
thrombelastography
thrombendarterectomy
thrombendarteriectomies
thrombendarteriectomy
thrombendoarterectomy
thrombi
thrombin (current term)
thrombin time
thrombinogen
thrombinogenesis
thrombins
thrombo-
thrombo-end-arterectomy
thrombo-endarterectomy
thrombo-endarteriectomy
thrombo-endo-arteriectomy
thrombo-endoarterectomy
thromboangiitis
thromboangiitis obliterans
thromboarteritis
thromboasthenia

Literary usage of Thrombin

Below you will find example usage of this term as found in modern and/or classical literature:

1. A Text-book of Physiology: For Medical Students and Physicians by William Henry Howell (1915)
"Once the thrombin exists in active condition it exhibits the remarkable property of precipitating the fibrinogen in the form of a gelatinous clot, ..."

2. The Harvey Lectures by Harvey Society of New York, New York Academy of Medicine (1918)
"Observations made upon the anti- thrombin contents of the blood and also upon what ... 1 thrombin 3 drops = Floating clot in 10 minutes. l thrombin 4 drops ..."

3. A Text-book of Physiology for Medical Students and Physicians by William Henry Howell (1911)
"We may conclude, therefore, that in all probability thrombin is a protein substance. The evidence at hand indicates that thrombin as such does not exist in ..."

4. A Text-book of Physiology for Medical Students and Physicians by William Henry Howell (1911)
"A solution of fibrinogen prepared as above clots readily upon the addition of blood-serum or of other solutions containing thrombin, and if the preparation ..."

5. A Text-book of Physiology for Medical Students and Physicians by William Henry Howell (1911)
"As a matter of fact, solutions of fibrinogen prepared as described sometimes clot, although much more slowly, when instead of a thrombin solution one adds a ..."

6. A Text-book of physiology for medical students and physicians by William Henry Howell (1913)
"Another, perhaps simpler, method of obtaining a strong preparation of thrombin is to treat fibrin with an 8 per cent, solution of sodium chlorid ..."

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