Medical Definition of Thrombosin

1. Protease (34 kD) generated in blood clotting that acts on fibrinogen to produce fibrin. Consists of two chains, A and B, linked by a disulphide bond. B chain has sequence homology with pancreatic serine proteases: cleaves at Arg Gly. Thrombin is produced from prothrombin by the action either of the extrinsic system (tissue factor + phospholipid) or, more importantly, the intrinsic system (contact of blood with a foreign surface or connective tissue). Both extrinsic and intrinsic systems activate plasma factor X to form factor Xa which then, in conjunction with phospholipid (tissue derived or platelet factor 3) and factor V, catalyses the conversion. This entry appears with permission from the Dictionary of Cell and Molecular Biology (11 Mar 2008)



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Lexicographical Neighbors of Thrombosin

thromboplastid
thromboplastin
thromboplastinogenaemia
thromboplastinogenase
thromboplastins
thrombopoieses
thrombopoiesis
thrombopoietin
thrombopoietins
thromboprophylaxis
thromboregulation
thrombose
thrombosed
thromboses
thrombosin (current term)
thrombosing
thrombosis
thrombospondin
thrombospondin 1
thrombospondins
thrombostasis
thrombosthenin
thrombotic
thrombotic disease due to protein c deficiency
thrombotic gangrene
thrombotic hydrocephalus
thrombotic infarct
thrombotic microangiopathy
thrombotic phlegmasia

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